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The Mystery of Male Pattern Hair Loss (MPHL)


What are the cause of hair loss>

Tiny male sex hormones called androgens that are responsible for growth also cause hair loss. These androgens produce dihydrotestosterone(DHT), which attach to the hair follicles and causeing them to shrivel and stop producing new hair. This is only noticed some men who are sensitive to DHT.

Is it Genetic?

Yes! The sensitivity of hair follicles to DHT is seen in genetically susceptible individuals. It is inherited by both the maternal and paternal genes.

Why the patterns?

The scalp is a combination of androgen-sensitive and ondrogen-independent hair follicles. The frontal scalp is the more sensitive region while the sides and the back are independent to the effects of DHT.

How is it diagnosed?

  • MPHL is clinically diagnosed by the pull test. A set of 60 hairs are pulled from the head. If more than 6 (d0.4) hairs detach then it might be a positive case for MPHL.
  • Evaluation of hair density and quality.
  • Folliscope is a non-invasive technique that produces enhanced images of the scalp.

What can I do about it?

  • There are pills like minoxidil and oral finasteride that are approved by the FDA. They promote hair regrowth and prevent progression of hair loss.
  • A hair transplant is based on the fact that hair follicles harvested from the back of the scalp retain their androgen-independent properties when implanted in the frontal scalp.


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